Dose Calibrator Simulated F-18 & Cu-64 (Ge-68)

The Dual Geometry “S” vial standard is the only direct NIST (National Institute of Standards and Technology) traceable dose calibrator standard for Ga-68 and F-18 available. The patented design provides you with the capability of calibration in the traditional vial or in the needed syringe position for your dose calibrator. Both the 0.5 millicuries (18.5 MBq) and 1.0 millicurie (37 MBq) standards contains Ge-68, with Ga-68 in secular equilibrium, and is sent with a calibration certificate and custom decay calendar. Independent studies at 17 major PET facilities worldwide involving over 100 different ion chambers have shown that ALL were incorrect in assaying Ga-68 and F-18 using manufacturing preset nuclide values on the ion chamber.

• Available is S, E & Serum (V) dose calibrator vial configurations.
• Dose calibrator standards are calibrated for Ge-68 activity against a traceable National Institute of Standards (NIST) source, using a pressurized ion chamber and cross calibrated for F-18 and Cu-64 calibration.
• All sources are shipped with a certificate of calibration, leak test certification, radiation safety and handling instructions and a custom decay calendar showing both the F-18 and Cu-64 equivalent activity.
• Each source is packaged in an individual lead shield.

Research & Publications

Zimmerman B E, Kinahan P, Beyer T. Development of a Traceable Calibration Methodology for Solid 68Ge/68Ga Sources Used as a Calibration Surrogate for 18F in Radionuclide Activity Calibrators. 2010;51(3):448.
https://jnm.snmjournals.org/content/51/3/448

Lodge M. Moving NaI(Tl) gamma counters towards improved quantitative accuracy for PET applications using traceable calibration sources. The Journal of Nuclear Medicine. 2014;55(suppl 1):2053.
https://jnm.snmjournals.org/content/55/supplement_1/2053

Bailey DL, Hofman MS, Forwood NJ, O’Keefe GJ, Scott AM, van Wyngaardt WM, Howe B, Kovacev O, Francis RJ; on behalf of ARTnet and the ProPSMA Trial Investigators. Accuracy of Dose Calibrators for 68Ga PET Imaging: Unexpected Findings in a Multicenter Clinical Pretrial Assessment. The Journal of Nuclear Medicine. 2018;59(4):636-638.
https://jnm.snmjournals.org/content/59/4/636

Zimmerman B. E.; Impact of Recent Change in the National Institute of Standards and Technology Standard for 18F on the Relative Response of 68Ge-Based Mock Syringe Dose Calibrator Standards. The Journal of Nuclear Medicine. 2015;56(9):1453.
https://jnm.snmjournals.org/content/56/9/1453

O’Brien N, Zimmer M, McDonald N, Spies S. Accuracy of F-18 calibration settings in commercial dose calibrators using a new traceable Ge-68 standard. The Journal of Nuclear Medicine. 2010;51(suppl 2):2112.
https://jnm.snmjournals.org/content/51/supplement_2/2112

Lockhart CM. Quantifying and reducing the effect of calibration error on PET/CT scanners. The Journal of Nuclear Medicine. 2011;52(2):218.
https://jnm.snmjournals.org/content/52/2/218