PET F-18 X-Cal System
This patented, RadQual-exclusive product allows for cross-calibration of your PET scanner, dose calibrator, and well detector utilizing NIST traceable Ge-68/Ga-68 sources. These sources are provided with certificates of calibration that also list the equivalent F-18 activity. This system is especially useful in multi-center imaging trials to assess bias and enable the correction of biases due to instrumentation factors for serial PET studies.
The X-Cal system contains an X-Cal cylinder phantom, a dose calibrator S-Vial, and a rod source. Also included is a base mount for the cylinder to use with the Data Spectrum ECT Phantom.
The cylinder phantom and rod source are made from the same batch of active epoxy as the dose calibrator source for optimal consistency from the dose calibrator measurement to the scanner measurement. The dose calibrator standard is calibrated to a well-characterized National Institute of Standard and Technology (NIST) Ge-68 standard. Activity contents of all of the sources are known at the 95% confidence level within +/- 2.5%.
A custom decay chart for Ge-68/Ga-68 and F-18 is provided for all of the sources with this system.
Research & Publications
Doot, R. K., Thompson, T., Greer, B. E., Allberg, K. C., Linden, H. M., Mankoff, D. A., & Kinahan, P. E. (2012). Early experiences in establishing a regional quantitative imaging network for PET/CT clinical trials. Magnetic resonance imaging, 30(9), 1291–1300.
https://www.sciencedirect.com/science/article/abs/pii/S0730725X12002007?via%3Dihub
Byrd, D., Christopfel, R., Arabasz, G., Catana, C., Karp, J., Lodge, M. A., Laymon, C., Moros, E. G., Budzevich, M., Nehmeh, S., Scheuermann, J., Sunderland, J., Zhang, J., & Kinahan, P. (2018). Measuring temporal stability of positron emission tomography standardized uptake value bias using long-lived sources in a multicenter network. Journal of medical imaging (Bellingham, Wash.), 5(1), 011016.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753626/
Doot, R. K., Pierce, L. A., 2nd, Byrd, D., Elston, B., Allberg, K. C., & Kinahan, P. E. (2014). Biases in Multicenter Longitudinal PET Standardized Uptake Value Measurements. Translational oncology, 7(1), 48–54.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3998681/
Byrd, D. W., Sunderland, J. J., Lee, T. C., & Kinahan, P. E. (2019). Bias in PET Images of Solid Phantoms Due to CT-Based Attenuation Correction. Tomography (Ann Arbor, Mich.), 5(1), 154–160.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403023/
Byrd, D. W., Doot, R. K., Allberg, K. C., MacDonald, L. R., McDougald, W. A., Elston, B. F., Linden, H. M., & Kinahan, P. E. (2016). Evaluation of Cross-Calibrated 68Ge/68Ga Phantoms for Assessing PET/CT Measurement Bias in Oncology Imaging for Single- and Multicenter Trials. Tomography (Ann Arbor, Mich.), 2(4), 353–360.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214172/
MacDonald, L. R., Perkins, A. E., & Tung, C. H. (2017). Longitudinal monitoring of reconstructed activity concentration on a clinical time-of-flight PET/CT scanner. Journal of medical imaging (Bellingham, Wash.), 4(1), 011004.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5120216/
Lodge, M. A., Holt, D. P., Kinahan, P. E., Wong, D. F., & Wahl, R. L. (2015). Performance assessment of a NaI(Tl) gamma counter for PET applications with methods for improved quantitative accuracy and greater standardization. EJNMMI physics, 2, 11.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4452125/
Press, R. H., Shu, H. G., Shim, H., Mountz, J. M., Kurland, B. F., Wahl, R. L., Jones, E. F., Hylton, N. M., Gerstner, E. R., Nordstrom, R. J., Henderson, L., Kurdziel, K. A., Vikram, B., Jacobs, M. A., Holdhoff, M., Taylor, E., Jaffray, D. A., Schwartz, L. H., Mankoff, D. A., Kinahan, P. E., … Buatti, J. M. (2018). The Use of Quantitative Imaging in Radiation Oncology: A Quantitative Imaging Network (QIN) Perspective. International journal of radiation oncology, biology, physics, 102(4), 1219–1235.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348006/
Mira, K., Wagatsuma, K., Iimori, T., Sawada, K., Kamiya, T., Samurai, M., Miyaji, N., Murata, T., & Sato, E. (2018). Multicenter study of quantitative PET system harmonization using NIST-traceable 68Ge/68Ga cross-calibration kit. Physica Medica, 52, 98-103.
https://www.sciencedirect.com/science/article/abs/pii/S1120179718311256